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What Are Prescription Drugs?
A prescription medication is a pharmaceutical drug that legally requires a medical prescription to be dispensed. In contrast, over-the-counter drugs can be obtained without a prescription. Prescription Medication are often strong medications, which is why they require a prescription from a doctor or dentist. There are three kinds of prescription drugs that are commonly misused.
Types of Commonly Misused Prescription Drugs
Opioids—used to relieve pain, such as Vicodin®, OxyContin®, or codeine
Depressants—used to relieve anxiety or help a person sleep, such as Valium® or Xanax®
Stimulants— used for treating attention deficit hyperactivity disorder (ADHD), such as Adderall® and Ritalin®
Addiction
Prescription medications that affect the brain, including opioid pain relievers, stimulants, and depressants, can cause physical dependence that could lead to addiction. Medications that affect the brain can change the way it works—especially when they are taken over a period of time or with increasing doses. They can change the reward system, making it harder for a person to feel good without the drug and possibly leading to intense cravings, which also make it hard to stop using.
Effects
Using opioids like oxycodone and codeine can cause you to feel sleepy, sick to your stomach, and constipated. At higher doses, opioids can make it hard to breathe properly and can cause overdose and death. Using stimulants like Adderall or Ritalin can make you feel paranoid (feeling like someone is going to harm you even though they aren’t). It also can cause your body temperature to get dangerously high and make your heart beat too fast. This is especially likely if stimulants are taken in large doses or in ways other than swallowing a pill. Using depressants like barbiturates can cause slurred speech, shallow breathing, sleepiness, disorientation, and lack of coordination. People who misuse depressants regularly and then stop suddenly may experience seizures. At higher doses, depressants can also cause overdose and death, especially when combined with alcohol.
A revolutionary medicine, The drug Adderall is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Adderall contains a combination of amphetamine and dextroamphetamine. Amphetamine and dextroamphetamine are central nervous system stimulants that affect chemicals in the brain and nerves that contribute to hyperactivity and impulse control.
The drug Adderall may also be used for purposes not listed in this medication guide.
The drug Adderall is a trading name for a combination drug called mixed amphetamine salts containing four salts of amphetamine. The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. Both enantiomers are stimulants but differ enough to give Adderall an effects profile distinct from those of racemic amphetamine or dextroamphetamine, which are marketed as Evekeo and Dexedrine/Zenzedi, respectively. Adderall is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used illicitly as an athletic performance enhancer, cognitive enhancer, appetite suppressant, and recreationally as a euphoriant. It is a central nervous system (CNS) stimulant of the phenethylamine class.
Warnings
The drug Adderall may be habit-forming, and this medicine is a drug of abuse. Tell your doctor if you have had problems with drug or alcohol abuse.
Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect.
Do not use this medicine if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine or have received a methylene blue injection.
Adderall may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder.
You may have blood circulation problems that can cause numbness, pain, or discoloration in your fingers or toes.
Call your doctor right away if you have: signs of heart problems – chest pain, feeling light-headed or short of breath; signs of psychosis – paranoia, aggression, new behavior problems, seeing or hearing things that are not real; signs of circulation problems – unexplained wounds on your fingers or toes.
You may not be able to use Adderall if you have glaucoma, overactive thyroid, severe agitation, moderate to severe high blood pressure, heart disease or coronary artery disease, vascular disease, or a history of drug or alcohol addiction.
Things to consider before taking Adderall
Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
You may not be able to use Adderall if you are allergic to any stimulant medicine. You may not be able to use Adderall if you have:
glaucoma;
overactive thyroid;
severe anxiety or agitation (stimulant medicine can make these symptoms worse);
high blood pressure;
heart disease or coronary artery disease;
vascular disease or hardening of the arteries; or
a history of drug or alcohol addiction.
Some medicines can interact with amphetamine and dextroamphetamine and cause a serious condition called serotonin syndrome. Tell your doctor about any other medications you are using. Be sure your doctor knows if you also take opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications. Symptoms of serotonin syndrome may include agitation, hallucinations (hearing or seeing things that are not real), coma, fast heart rate, dizziness, sweating, feeling hot, muscle rigidity or shakiness, seizures, nausea, vomiting, or diarrhea. Stop Adderall immediately if you experience these symptoms.
Stimulants have caused stroke, heart attack, and sudden death in certain people.
Tell your doctor if you have:
heart problems or a congenital heart defect;
high blood pressure; or
a family history of heart disease or sudden death.
To make sure Adderall is safe for you, tell your doctor if you or anyone in your family has ever had:
depression, anxiety, mental illness, bipolar disorder, psychosis, problems with aggression, or suicidal thoughts or actions;
motor tics (muscle twitches) or Tourette’s syndrome;
seizures or epilepsy;
an abnormal brain wave test (EEG); or
liver or kidney disease; or
blood circulation problems in the hands or feet.
Taking Adderall during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
The medications in Adderall (amphetamine and dextroamphetamine) can pass into breast milk and may harm a nursing baby. You should not breastfeed while you are using this medicine.
Adderall is not approved for use by anyone younger than 3 years old.
How to take Adderall?
Take Adderall exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
The drug Adderall may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
You may take Adderall with or without food, first thing in the morning.
Do not crush, chew, break, or open an extended-release capsule. Swallow it whole.
To make swallowing easier, you may open the capsule and sprinkle the medicine into a spoonful of applesauce. Swallow right away without chewing. Do not save the mixture for later use.
While using this medicine, your doctor will need to check your progress at regular visits. Tell any doctor who treats you that you are using this medicine.
Adderall can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.
Store at room temperature away from moisture, heat, and light.
Keep track of your medicine. Adderall is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Adderall Dosing information
Usual Adult Dose of Adderall for Attention Deficit Disorder:
IR: -Initial Dose: 5 mg orally 1 or 2 times a day -Maintenance Dose: Daily dose may be raised in 5 mg increments at weekly intervals until optimal response is obtained. -Maximum Dose: Only in rare cases will it be necessary to exceed 40 mg per day.
XR: Patients starting treatment for the first time or switching from another medication: -Initial Dose: 20 mg orally once a day
Comments: -IR: The first dose should be given upon awakening; 1 to 2 additional doses should be given at intervals of 4 to 6 hours. -Where possible, drug administration should be interrupted occasionally to determine if continued therapy is required.
Use: As part of a total treatment program for Attention Deficit Hyperactivity Disorder (ADHD).
Usual Adult Dose of Adderall for Narcolepsy:
IR: -Initial Dose: 10 mg orally per day in divided doses -Maintenance Dose: Daily dose may be raised in 10 mg increments at weekly intervals until optimal response is obtained.
Comments: -The first dose should be given on awakening; 1 to 2 additional doses should be given at intervals of 4 to 6 hours. -The usual dose is 5 to 60 mg per day in divided doses, depending on the individual patient response. -Dosage should be reduced if bothersome adverse reactions (e.g., insomnia, anorexia) appear.
Use: Narcolepsy treatment
Usual Pediatric Dose of Adderall for Attention Deficit Disorder:
IR: Age 3 to 5 Years: -Initial Dose: 2.5 mg orally per day -Maintenance Dose: Daily dose may be raised in 2.5 mg increments at weekly intervals until optimal response is obtained.
Age 6 to 17 Years: -Initial Dose: 5 mg orally 1 or 2 times a day -Maintenance Dose: Daily dose may be raised in 5 mg increments at weekly intervals until optimal response is obtained. -Maximum Dose: Only in rare cases will it be necessary to exceed 40 mg per day.
XR: Age 6 to 12 Years (starting treatment for the first time or switching from another medication): -Initial Dose: 5 or 10 mg orally once a day in the morning -Maintenance Dose: Daily dose may be raised in 5 to 10 mg increments at weekly intervals. -Maximum Dose: 30 mg/day
Age 13 to 17 Years (starting treatment for the first time or switching from another medication): -Initial Dose: 10 mg orally once a day -Maintenance Dose: Daily dose may be increased to 20 mg/day after one week if symptoms are not adequately controlled. -Maximum Dose: 30 mg/day
Comments: -IR: The first dose should be given on awakening; 1 to 2 additional doses should be given at intervals of 4 to 6 hours. -Where possible, drug administration should be interrupted occasionally to determine if continued therapy is required.
Use: As part of a total treatment program for Attention Deficit Hyperactivity Disorder (ADHD).
Usual Pediatric Dose of Adderall for Narcolepsy:
IR: Age 6 to 11 Years: -Initial Dose: 5 mg orally per day in divided doses -Maintenance Dose: Daily dose may be raised in 5 mg increments at weekly intervals until optimal response is obtained.
Age 12 Years and Older: -Initial Dose: 10 mg orally per day in divided doses -Maintenance Dose: Daily dose may be raised in 10 mg increments at weekly intervals until optimal response is obtained.
Comments: -The first dose should be given on awakening; 1 to 2 additional doses should be given at intervals of 4 to 6 hours. -The usual dose is 5 to 60 mg per day in divided doses, depending on the individual patient response. -Dosage should be reduced if bothersome adverse reactions (e.g., insomnia, anorexia) appear. -Narcolepsy rarely occurs in children under 12 years of age.
Use: Narcolepsy treatment
What do I do if I miss a dose?
Take the missed dose as soon as you remember, but not late in the day. Skip the missed dose if it is almost evening. Do not take extra medicine to make up for the missed dose.
What happens if I overdose on Adderall?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Adderall could be fatal.
Overdose symptoms may include restlessness, tremors, muscle twitches, rapid breathing, confusion, hallucinations, panic, aggressiveness, muscle pain or weakness, and dark-colored urine. These symptoms may be followed by depression and tiredness. Other overdose symptoms include nausea, vomiting, diarrhea, stomach pain, uneven heartbeats, feeling light-headed, fainting, seizure (convulsions), or coma.
What should I avoid when taking Nembutal?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid drinking fruit juices or taking vitamin C at the same time you take Adderall. These can make your body absorb less of the medicine.
Side effects of Adderall
Get emergency medical help if you have signs of an allergic reaction to Adderall: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Adderall may cause serious side effects. Call your doctor at once if you have:
signs of heart problems – chest pain, trouble breathing, feeling like you might pass out;
signs of psychosis – hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
signs of circulation problems – numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
a seizure (convulsions);
muscle twitches (tics); or
changes in your vision.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
The drug Adderall can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Common side effects of Adderall may include:
stomach pain;
loss of appetite;
weight loss;
mood changes;
feeling nervous;
fast heart rate;
headache;
dizziness;
sleep problems (insomnia); or
dry mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Adderall interactions with other drugs?
Ask your doctor before using a stomach acid medicine (including Alka-Seltzer or sodium bicarbonate). Some of these medicines can change the way your body absorbs Adderall and may increase side effects.
information about Adderall Tell your doctor about all your current medicines and any you start or stop using, especially:
buspirone, lithium, selective serotonin reuptake inhibitor (SSRI) drugs (including citalopram, fluoxetine, paroxetine, sertraline, others), tricyclic antidepressants (amitriptyline, others) or other medicine to treat depression or mental illness;
blood pressure medicine;
heartburn medicine;
a blood thinner such as warfarin, Coumadin, or Jantoven;
cold or allergy medicine that contains a decongestant;
opioid (narcotic) medicine; or
seizure medicine.
This list is not complete and many other drugs can interact with Adderall. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. {Drugs.com}{Wikipedia}.
It is sold under various brand names such as Roxicodone and OxyContin (which is the extended-release form), and is a strong, semi-synthetic opioid used medically for the treatment of moderate to severe pain. It is highly addictive and is a commonly abused drug. It is usually taken by mouth and is available in immediate-release and controlled-release formulations. The onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation. In the United Kingdom, it is available by injection. Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin.
Oxycodone was first made in Germany in 1916 from thebaine. It is on the World Health Organization’s List of Essential Medicines. It is available as a generic medication. In 2020, it was the 54th most commonly prescribed medication in the United States, with more than 12 million prescriptions. A number of abuse-deterrent formulations are available, such as in combination with naloxone or naltrexone.
Medical uses of Oxycodone
There are many uses of Oxycodone. It is used for managing moderate to severe acute or chronic pain when other treatments are not sufficient. It may improve the quality of life in certain types of pain. It is unclear if use in chronic pain results in improved quality of life or ongoing pain relief.
Oxycodone is available as a controlled-release tablet, intended to be taken every 12 hours. A July 1996 study independent of Purdue Pharma, the drug’s originator, found the controlled-release formulation had a variable duration of action ranging from 10 to 12 hours. A 2006 review found that controlled-release oxycodone is comparable to immediate-release oxycodone, morphine, and hydromorphone in the management of moderate to severe cancer pain, with fewer side effects than morphine. The author concluded that the controlled-release form is a valid alternative to morphine and a first-line treatment for cancer pain. In 2014, the European Association for Palliative Care recommended oxycodone by mouth as a second-line alternative to morphine by mouth for cancer pain.
In the U.S., extended-release oxycodone is approved for use in children as young as eleven years old. The approved uses are for the relief of cancer pain, trauma pain, or pain due to major surgery, in children already treated with opioids, who can tolerate at least 20 mg per day of oxycodone; this provides an alternative to Duragesic (fentanyl), the only other extended-release opioid analgesic approved for children.
Caution
You should not use oxycodone if you have severe asthma breathing problems, or a blockage in your stomach or intestines.
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Taking oxycodone during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Oxycodone can slow or stop your breathing. This is more likely in elderly or ill patients but can occur in anyone taking this medicine.
Things to be wary of before taking Oxycodone
You should not use oxycodone if you are allergic to it, or if you have:
severe asthma or breathing problems; or
a blockage in your stomach or intestines.
You should not use this medicine if you are already using a similar opioid medicine and are tolerant to it. Do not use this medicine if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine or have received a methylene blue injection.
Most brands of oxycodone are not approved for use in people under the age of 18. OxyContin should not be given to a child younger than 11 years old.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
breathing problems, sleep apnea;
a head injury, brain tumor, or seizures;
drug or alcohol addiction, or mental illness;
lung disease;
liver or kidney disease;
thyroid disorder;
adrenal disease (such as Addison’s disease;
urination problems; or
problems with your gallbladder or pancreas.
If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. Tell your doctor if you are pregnant before using oxycodone. If you become pregnant while taking oxycodone, do not stop your medication suddenly without talking to your doctor. You may need to decrease your medicine gradually.
Ask a doctor before using oxycodone if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.
How to use oxycodone
Take oxycodone exactly as prescribed. Follow the directions on your prescription label and read all medication guides. Never use this medicine in larger amounts or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of oxycodone.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Stop taking all other around-the-clock opioid pain medicines when you start taking extended-release oxycodone.
Take it with food.
Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.
If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing. Do not save it for later use.
Never crush or break an oxycodone
Never crush or break an oxycodone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause death.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
You should not stop using oxycodone suddenly. Follow your doctor’s instructions about gradually decreasing your dose.
Store at room temperature, away from heat, moisture, and light. Keep track of your medicine. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
I missed my Oxycodone dose
Since oxycodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.
What do I do if I overdose on Oxycodone?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.
Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don’t wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.
Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.
Things to avoid when taking oxycodone?
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Avoid medication errors. Always check the brand and strength of oxycodone you get from the pharmacy.
Side effects of Oxycodone: Oxycodone Medical uses
The most common side effects of oxycodone include reduced sensitivity to pain, delayed gastric emptying, euphoria, anxiolysis, feelings of relaxation, and respiratory depression. Common side effects of oxycodone include constipation (23%), nausea (23%), vomiting (12%), somnolence (23%), dizziness (13%), itching (13%), dry mouth (6%), and sweating (5%). Less common side effects (experienced by less than 5% of patients) include loss of appetite, nervousness, abdominal pain, diarrhea, urinary retention, dyspnea, and hiccups.
Oxycodone Medical uses and side effects. Most side effects generally become less intense over time, although issues related to constipation are likely to continue for the duration of use. Oxycodone in combination with naloxone in managed-release tablets, has been formulated to both deter abuse and reduce opioid-induced constipation.
Call your doctor at once if you have:
noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
a slow heart rate or weak pulse;
cold, clammy skin;
a light-headed feeling, like you might pass out;
confusion, unusual thoughts or behavior;
seizure (convulsions);
low cortisol levels – nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
high levels of serotonin in the body – agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.
Oxycodone interaction with other drugs
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.
Oxycodone Medical uses and side effects, Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
other opioids – opioid pain medicine or prescription cough medicine;
sedative medications including alprazolam or Xanax, clonazepam or Klonopin, diazepam or Valium, lorazepam or Ativan, temazepam or Restoril and others;
sleeping pills;
muscle relaxants or tranquilizers;
medicine for depression, anxiety, or other mental illness;
medicine for Parkinson’s disease;
migraine headache treatment; or
medications used for the prevention of nausea and vomiting.
cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (“water pill”);
medicines for motion sickness, irritable bowel syndrome, or overactive bladder;
This list is not complete and many other drugs may interact with oxycodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. {Drugs.com}{Wikipedia}
Xanax Uses prescriptions and side effects, Xanax is a drug that works by enhancing the activity of certain neurotransmitters in the brain.
It is used to treat anxiety disorders and anxiety caused by depression.
Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia)
Also known as Alprazolam is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. It is most commonly used in the management of anxiety disorders, specifically panic disorder or generalized anxiety disorder (GAD). Other uses include the treatment of chemotherapy-induced nausea, together with other treatments. GAD improvement occurs generally within a week. Xanax is generally taken orally (by mouth).
Medical uses of Xanax (Alprazolam)
Alprazolam is mostly used in the management of anxiety disorders, panic disorders, and nausea due to chemotherapy. Alprazolam is indicated for the treatment of generalized anxiety disorder and panic disorder with or without agoraphobia in adults.
Panic disorder
Alprazolam is effective in the relief of moderate to severe anxiety and panic attacks. Alprazolam is not recommended in Australia for the treatment of panic disorder because of concerns regarding tolerance, dependence, and abuse. Most evidence shows that the benefits of alprazolam in treating panic disorder last only four to ten weeks. However, people with panic disorder have been treated on an open basis for up to eight months without apparent loss of benefit.
Alprazolam is recommended by the World Federation of Societies of Biological Psychiatry (WFSBP) for treatment-resistant cases of panic disorder where there is no history of tolerance or dependence.
Anxiety disorders
Anxiety associated with depression is responsive to alprazolam. Clinical studies have shown that the effectiveness is limited to four months for anxiety disorders. However, the research into the antidepressant properties of alprazolam is poor and has only assessed its short-term effects against depression. In one study, some long-term, high-dosage users of alprazolam developed reversible depression.
In the US, alprazolam is FDA-approved for the management of anxiety disorders, a condition corresponding most closely to the American Psychological Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) diagnosis of generalized anxiety disorder, or the short-term relief of symptoms of anxiety.
In the UK, alprazolam is recommended for short-term treatment, from two to four weeks, of severe acute anxiety.
Nausea due to chemotherapy
Alprazolam may be used in combination with other medications for chemotherapy-induced nausea and vomiting.
Caution
Xanax can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol.
MISUSE OF XANAX CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Do not stop using Xanax without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use. Some withdrawal symptoms may last up to 12 months or longer.
Get medical help right away if you stop using Xanax and have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, or thoughts about suicide.
Xanax is a federally controlled substance (C-IV) because it can be abused or lead to dependence. Keep this medicine in a safe place to prevent misuse and abuse. Selling or giving away this Xanax may harm others, and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines, or street drugs.
Points to note before taking this medicine
You should not take Xanax if:
you also take antifungal medicine such as itraconazole ketoconazole; or
you have a history of allergic reaction to any benzodiazepine (alprazolam, lorazepam, diazepam, Ativan, Valium, Versed, Klonopin, and others).
To make sure Xanax is safe for you, tell your doctor if you have ever had:
breathing problems;
drug or alcohol addiction;
depression, mood problems, or suicidal thoughts or behavior; or
kidney or liver disease.
Tell your doctor if you are pregnant or plan to become pregnant. If you use Xanax during pregnancy, your baby could be born with life-threatening withdrawal symptoms and may need medical treatment for several weeks.
You should not breastfeed.
If you do breastfeed, tell your doctor if you notice drowsiness or feeding problems in the baby.
Not approved for use by anyone younger than 18 years old.
Knowing the exact dose to take
Usual Adult Dose for Anxiety:
Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day
Usual Adult Dose for Panic Disorder:
Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day
Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day
Xanax Uses prescriptions and side effects
Usual Geriatric Dose for Anxiety:
Usual Geriatric Dose for Panic Disorder:
Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day
Extended-release tablets: -Initial dose: 0.5 mg orally once a day
Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage
Overdosing on Xanax
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.
Overdose symptoms may include severe drowsiness, confusion, slurred speech, muscle weakness, loss of balance or coordination, feeling light-headed, slow heartbeats, weak or shallow breathing, fainting, or coma.
What to avoid while taking Xanax
Avoid drinking alcohol. Dangerous side effects or death could occur.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Side effects of Xanax
Get emergency medical help if you have signs of an allergic reaction to Xanax: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
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Common side effects of Xanax may include:
drowsiness; or
feeling light-headed.
Xanax may cause serious side effects. Call your doctor at once if you have:
weak or shallow breathing;
a light-headed feeling, like you might pass out;
a seizure;
hallucinations, risk-taking behavior;
increased energy, decreased need for sleep;
racing thoughts, being agitated or talkative;
double vision; or
jaundice (yellowing of the skin or eyes).
Drowsiness or dizziness may last longer in older adults. Use caution to avoid falling or accidental injury.
After you stop using Xanax, get medical help right away if you have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, suicidal thoughts or actions.
Some withdrawal symptoms may last up to 12 months or longer after stopping this medicine suddenly. Tell your doctor if you have ongoing anxiety, depression, problems with memory or thinking, trouble sleeping, ringing in your ears, a burning or prickly feeling, or a crawling sensation under your skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Xanax interaction with other drugs
Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.
Taking Xanax with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Many drugs can interact with alprazolam, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. {Drugs.com}{Wikipedia}
Subutex Treating Opioid use disorder and side effects
Subutex Treating Opioid Use Disorder and Side Effects, Subutex also known as Buprenorphine/naloxone is an opioid medication. It falls under the group of medications called narcotics.
Subutex sublingual tablets are used to treat opioid addiction. Other forms of buprenorphine are used to treat moderate to severe pain.
Subutex is a fixed-dose combination medication that includes buprenorphine and naloxone. It is used to treat opioid use disorder and reduces the mortality of opioid use disorder by 50% (by reducing the risk of overdose on full-agonist opioids such as heroin or fentanyl). It relieves cravings for use and withdrawal symptoms. Subutex is available for use in two different forms, under the tongue or in the cheek.
Medical uses of Subutex
Buprenorphine/naloxone is used for the treatment of opioid use disorder. Long-term outcomes are generally better with the use of buprenorphine/naloxone than attempts at stopping opioid use altogether. This includes a lower risk of overdose with medication use. Due to the high binding affinity and low activation at the opioid receptor, cravings and withdrawal for opioids are decreased while preventing a person from getting high and relapsing on another opioid. The combination of the two medications is preferred over buprenorphine alone for maintenance treatment due to the presence of naloxone in the formulation, which is believed to help discourage intravenous use. However, the belief that the addition of naloxone provides this benefit has been called into question, and posters on drug-related online forums have stated that they were able to attain a high by injecting preparations of buprenorphine despite being combined with naloxone.
Buprenorphine/naloxone has been found to be effective for treating opioid dependence and serves as a recommended first-line medication according to the U.S. National Institute on Drug Abuse. The medication is an effective maintenance therapy for opioid dependence and has generally similar efficacy to methadone. Both treatments — buprenorphine/naloxone and methadone — are substantially more effective than abstinence-based treatment. Prescribers need a Drug Addiction Treatment Act (DATA 2000) waiver to prescribe buprenorphine/nalaxone for opioid dependence.
Caution
Subutex sublingual tablets are not for use as a pain medication.
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Things to note before taking Subutex
You should not use Subutex if you are allergic to buprenorphine, or:
if you have used another opioid medicine within the past 4 hours.
To make sure Subutex is safe for you, tell your doctor if you have ever had:
abnormal curvature of the spine that affects breathing;
kidney or liver disease (especially hepatitis B or C);
enlarged prostate, urination problems;
a head injury or brain tumor;
alcoholism, hallucinations, mental illness; or
problems with your stomach, gallbladder, adrenal gland, or thyroid.
If you use Subutex while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.
Buprenorphine can pass into breast milk and may cause drowsiness, and breathing problems in a nursing baby. Ask your doctor about any risks.
Subutex sublingual is usually taken only at the start of treatment for addiction. Most people are later switched to another medicine that contains this medicine (Bunavail, Sublocade, Suboxone, Zubsolv).
You may receive your first doses of Subutex sublingual in a hospital or clinic setting until your condition improves.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Rinse your mouth with water after the Subutex sublingual tablet dissolves. Wait one hour after the medicine dissolves to brush your teeth to prevent damage to the teeth and gums. Do not chew the tablet or swallow it whole.
If your doctor has prescribed more than 2 tablets per dose, place the correct number of tablets under your tongue at the same time and allow them to dissolve completely.
Do not eat or drink anything until the tablet has completely dissolved in your mouth.
You should receive regular dental checkups while using Subutex.
You may need frequent blood tests to check your liver function.
If you need surgery, tell the surgeon ahead of time that you are using Subutex.
Never crush or break a Subutex pill to inhale the powder or mix it into a liquid to inject the drug into your vein. Doing so could result in death.
Any medical care provider who treats you should know that you are being treated for opioid addiction and that you are taking Subutex sublingual. Make sure your family members know how to provide this information in case they need to speak for you during an emergency.
Do not stop using Subutex suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Subutex.
Store at room temperature away from moisture and heat. Keep track of your medicine. Subutex is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Do not keep leftover opioid medication. Just one dose can cause death if someone uses this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
Subutex Dosing information
Usual Adult Dose for Opiate Dependence – Maintenance:
SUBLINGUAL Tablets: Following a 2-day induction: -Adjust dose in 2 to 4 mg increments/decrements to a level that holds the patient in treatment and suppresses opioid withdrawal signs and symptoms -Target dose: 16 mg sublingually once a day; range 4 to 24 mg/day -Maximum dose: 24 mg/day; higher doses have not shown a clinical advantage
Comments: -Buprenorphine with naloxone is the preferred drug for maintenance treatment; unsupervised maintenance treatment with buprenorphine should be limited to those who cannot tolerate buprenorphine-naloxone. -When determining prescription quantity for unsupervised administration, consider the patient’s level of stability, the security of his or her home situation, and other factors likely to affect the ability to manage supplies of take-home medications.
-Monthly doses should allow for a minimum of 26 days between doses; occasional delays in dosing of up to 2 weeks are not expected to have a clinically significant impact on the treatment effect.
Usual Adult Dose for Opiate Dependence – Induction:
Treatment should be initiated when objective and clear signs of moderate opioid withdrawal appear, and -at least 4 hours have elapsed since the last use of heroin or other short-acting opioids -at least 24 hours have elapsed since the last use of methadone or other long-acting opioids
INDUCTION: Day 1: 8 mg sublingually once a day (may give in 2 to 4 mg increments, if preferred) Day 2: 16 mg sublingually once a day
Comments: -This drug should be used as part of a complete treatment plan to include counseling and psychosocial support. -Buprenorphine (without naloxone) is the preferred drug for induction; following induction, unsupervised administration should be limited to those patients who cannot tolerate buprenorphine/naloxone. -Adequate treatment doses should be given as soon as possible as gradual induction over several days has led to higher dropout rates.
Uses: For the treatment of opioid dependence and is preferred for induction.
What to do if you miss a dose
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Subutex overdose
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Subutex overdose can be fatal, especially in a child or other person using the medicine without a prescription.
Overdose symptoms may include extreme drowsiness or weakness, cold or clammy skin, pinpoint pupils, slow heart rate, weak pulse, very slow breathing, or coma.
What you should avoid while taking Subutex sublingual
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid driving or operating machinery until you know how Subutex will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Side effects of Subutex
Get emergency medical help if you have signs of an allergic reaction to Subutex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue-colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
any problems with your teeth or gums;
noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
problems with thinking, blurred vision, slurred speech, a light-headed feeling, like you might pass out;
chest pain, trouble breathing, slow heartbeat, or weak pulse;
opioid withdrawal symptoms – shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain;
low cortisol levels – vomiting, dizziness, worsening tiredness or weakness; or
liver problems – nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Seek medical attention right away if you have symptoms of serotonin syndrome, Subutex Treating Opioid use disorder and side effects. such as agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Subutex Opioid side effects
Common Subutex side effects may include:
constipation, nausea, vomiting;
headache;
increased sweating;
sleep problems (insomnia); or
pain anywhere in your body.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Subutex Treating side effects
Interaction of Subutex sublingual with other drugs?
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.
Subutex Treating Opioid use disorder and side effects. Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (“water pill”);
medicines for motion sickness, irritable bowel syndrome, or overactive bladder;
other opioid medications – opioid pain medicine or prescription cough medicine;
a sedative like Valium – diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;
drugs that make you sleepy or slow your breathing – a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or
drugs that affect serotonin levels in your body – a stimulant, or medicine for depression, Parkinson’s disease, migraine headaches, serious infections, or nausea and vomiting.
This list is not complete. Other drugs may interact with buprenorphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. {Wikipedia}{Drugs.com}
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